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Biofluids

At CAVS, Dr. Greg Burgreen and his team of computational engineers are using CFD to simulate and improve novel medical therapies for both adults and children. Our research has been instrumental in the awarding of several US and international patents on biomedical devices. Projects include:

  • drug delivery in advanced models of diseased human lungs
  • cardiovascular artificial organ development, involving ventricular assist devices (artificial hearts) and oxygenation devices (artificial lungs)
  • state-of-the-art models of blood damage and thrombosis

References:

Walters DK, Burgreen GW, Hester RL, Thompson D, Pruett WA, Wang X. (2014). Cyclic Breathing Simulations in Large-Scale Models of the Lung Airway From the Oronasal Opening to the Terminal Bronchioles. ASME Journal of Fluids Engineering 136(10):1-10. doi:10.1115/1.4027485. 
Madhani SP, Frankowski BJ, Burgreen GW, Antaki JF, Kormos R, D'Cunha J, Federspiel WJ. (2017) In vitro and in vivo evaluation of a novel integrated wearable artificial lung . Journal of Heart and Lung Transplantation 36(7):806-811.
Majumdar S, Patil CN, Ladner-Threadgill T, Randolph E, Burgreen GW, Kermode JC. (2017) Platelet activation and erythrocyte lysis during brief exposure of blood to pathophysiological shear stress in vitro. Clin Hemorheol Microcirc. doi: 10.3233/CH-170256. ​

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